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Rapid entry to phenanthroindolizidine alkaloids via an acid-catalysed acyliminium ion-electrocyclization cascade.

Max St PierreChristine J KempthorneDavid K LiscombeJames McNulty
Published in: Organic & biomolecular chemistry (2023)
A rapid total synthesis of seco-phenanthroindolizidine alkaloids was achieved involving a one-pot acid catalyzed deprotection- condensation-electrocyclization strategy. This synthetic route provided a concise synthesis of (±)-seco-antofine and (±)-septicine in only 4 steps with an overall yield of 22% and 17%, respectively.
Keyphrases
  • loop mediated isothermal amplification
  • sensitive detection