Cervical Intraepithelial Neoplasia grade 2 biopsy: Do p16INK4a and Ki-67 biomarkers contribute to the decision to treat? A cross-sectional study.
Amanda Leal FerreiraNasle Domingues DibeBruna Rodrigues de PaivaElyzabeth Avvad PortariDione Corrêa de Araújo DockNilma Valéria Caldeira FerreiraSaint Clair Dos Santos Gomes-JúniorFábio Bastos RussomanoCecília Vianna de AndradePublished in: Sao Paulo medical journal = Revista paulista de medicina (2023)
Negative p16INK4a and Ki67 immunohistochemical staining can assure absence of a higher-grade lesion in more than 85% of patients with CIN2 biopsies and can be used to prevent overtreatment of these patients. Positive IHC staining for p16INK4a and Ki-67 did not predict CIN3 in patients with CIN2 biopsies.