Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity.
Isabel Ortuño-LizaránThomas G BeachGeidy E SerranoDouglas G WalkerCharles H AdlerNicolás CuencaPublished in: Movement disorders : official journal of the Movement Disorder Society (2018)
These data suggest that phosphorylated α-synuclein accumulates in the retina in parallel with that in the brain, including in early stages preceding development of clinical signs of parkinsonism or dementia. Therefore, the retina may provide an in vivo indicator of brain pathology severity, and its detection could help in the diagnosis and monitoring of disease progression. © 2018 International Parkinson and Movement Disorder Society.
Keyphrases
- diabetic retinopathy
- optic nerve
- resting state
- white matter
- functional connectivity
- mild cognitive impairment
- cerebral ischemia
- electronic health record
- cognitive impairment
- parkinson disease
- loop mediated isothermal amplification
- drug induced
- machine learning
- brain injury
- deep learning
- quantum dots
- sensitive detection