Tannins-enriched fraction of TeMac™ protects against aluminum chloride induced Alzheimer's disease-like pathology by modulating aberrant insulin resistance and alleviating oxidative stress in diabetic rats.
Bruno Dupon Akamba AmbambaFils Armand EllaDany Joël Ngassa NgoumenRuth Edwige Dibacto KemadjouNicoline Injoh AgweFlorine Essouman MbappeMartin FonkouaDamaris Mandob EnyegueJudith Laure NgondiPublished in: Journal of ethnopharmacology (2024)
Our findings indicate that TEF of TeMac™ prevents Alzheimer's-type pathology linked to insulin resistance in rats. TEF of TeMac™ may be a potential drug candidate for the treatment of diabetes-associated cognitive impairment.
Keyphrases
- diabetic rats
- oxidative stress
- cognitive impairment
- insulin resistance
- type diabetes
- cognitive decline
- cardiovascular disease
- glycemic control
- ischemia reperfusion injury
- dna damage
- adipose tissue
- induced apoptosis
- signaling pathway
- polycystic ovary syndrome
- metabolic syndrome
- high fat diet
- risk assessment
- mild cognitive impairment
- climate change
- high glucose
- electronic health record
- smoking cessation