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Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.

Eszter MolnárDominika RittlerMarcell BaranyiMichael GruschWalter BergerBalázs DömeJózsef TóváriClemens AignerJózsef TímárTamás GarayBalazs Hegedüs
Published in: BMC cancer (2018)
Our data suggests that combined blocking of RAF and MEK may achieve increased therapeutic response in non-V600 BRAF mutant tumors.
Keyphrases
  • wild type
  • induced apoptosis
  • pi k akt
  • cell cycle arrest
  • metastatic colorectal cancer
  • electronic health record
  • big data
  • oxidative stress
  • signaling pathway
  • cell death
  • cell proliferation
  • deep learning