Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer.

Qiaoqi SuiDingxin LiuWu JiangJinghua TangLingheng KongKai HanLeen LiaoYuan LiQingjian OuBin-Yi XiaoGuochen LiuYihong LingJiewei ChenZexian LiuZhixiang ZuoZhizhong PanPenghui ZhouJian ZhengPei-Rong Ding

Published in: Journal for immunotherapy of cancer (2021)

DKK1 suppressed the antitumor immune reaction through the GSK3β/E2F1/T-bet axis in CD8+ T cells. Elevated serum DKK1 predicted poor tumor response to PD-1 blockade in dMMR/MSI CRCs, and DKK1 neutralization may restore sensitivity to PD-1 blockade.

Keyphrases

signaling pathway
cell proliferation