pH-Responsive Nanofibers for Precise and Sequential Delivery of Multiple Payloads.

Effective combination therapies can be achieved by programming materials for controlling release sequence, timing, and dose of multiple payloads. Herein, we synthesize dextran esters by coesterification of dextran, which display responsive properties at a precise pH threshold between 5.0 and 7.0. Multilayers electrospun nanofibers are prepared so that three different payloads are entrapped in three different dextran esters. The release of the three drugs can be sequentially and independently activated by a gradual increase of pH value. Because both pH threshold and release kinetics are matching conditions encountered by aliments along the gastrointestinal tract, these dextran ester multilayer nanofibers are promising for oral drug delivery.