Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Robert B FlintRob Ter HeineEdwin SpaansDavid M BurgerJohan C A de KlerkKarel AllegaertCatherijne A J KnibbeSinno H P Simons

Published in: European journal of clinical pharmacology (2018)

We propose to improve intermittent ibuprofen-dosing regimens by starting with a high first dose followed by a twice-daily maintenance dosing regimen that requires increase over time and should be continued until sufficient effect has been achieved.

Keyphrases

low birth weight
gestational age
pregnant women
physical activity
high intensity
preterm infants