Recurrence of Primary Sclerosing Cholangitis After Liver Transplant in Children: An International Observational Study.
Mercedes MartinezEmily R PeritoPamela L ValentinoCara L MackMadeleine AumarAnnemarie BroderickLaura G DraijerEleonora D T FagundesKatryn N FuruyaNitika GuptaSimon HorslenMaureen M JonasBinita M KamathNanda KerkarKyung Mo KimKaija-Leena KolhoBart G P KootTrevor J LabordaChristine K LeeKathleen M LoomesTamir MilohDouglas MogulSaeed MohammedNadia OvchinskyGirish RaoAmanda RicciutoAlexandre Rodrigues FerreiraKathleen B SchwarzVratislav SmolkaAtsushi TanakaMary E M TessierVenna L VenkatBernadette E VitolaMarek WoynarowskiMelissa ZerofskyMark R DeneauPublished in: Hepatology (Baltimore, Md.) (2021)
The incidence of rPSC in this cohort was higher than previously reported, and was associated with increased morbidity and mortality. Patients with rPSC appeared to have a more aggressive, immune-reactive phenotype. These findings underscore the need to understand the immune mechanisms of rPSC, to lay the foundation for developing new therapies and improve outcomes in this challenging population.