Tropaeolum majus L. and low dose gamma radiation suppress liver carcinoma development via EGFR-HER2 signaling pathway.
Asmaa M AboulMagdNoheir H SherifAsmaa A HassanEl-Moataz Bellah El-NaggarIman H El-KhashabEl-Sayed El-GhalyPublished in: Natural product research (2022)
Hepatocellular carcinoma (HCC) is one of the most fatal cancers around the world and remain asymptomatic in early stage. An alcoholic extract prepared from leaves of Tropaeolum majus L. (Tropaeolaceae) was assessed for its potential activity against diethylnitrosamine-induced liver carcinoma in vivo . Oral administration of the extract significantly decreased the inflammatory marker translation NF-kB and supressed HCC progression in combination with 0.5 Gy gamma radiation via EGF-HER-2 pathway. Histopathological and immunohistopathological features also showed the recovery of a hepatic architecture. Immunohistochemical study showed the T. majus and LDR enhancement effect on proapoptotic markers (caspase-3 and Bax) and inhibition of anti-apoptotic factor (BCl2). HPLC-DAD-MS n analysis of the extract revealed the annotation of twelve compounds. T. majus could mediate a defensive influence against diethylnitrosamine-induced hepatocarcinogenesis and serve as a respectable option in amelioration of the hepatocellular carcinoma development in combination with low dose of gamma radiation.
Keyphrases
- low dose
- oxidative stress
- signaling pathway
- ms ms
- diabetic rats
- early stage
- induced apoptosis
- high glucose
- anti inflammatory
- cell death
- high dose
- small cell lung cancer
- mass spectrometry
- simultaneous determination
- pi k akt
- multiple sclerosis
- single cell
- squamous cell carcinoma
- epidermal growth factor receptor
- liver injury
- tyrosine kinase
- lymph node
- rna seq
- nuclear factor
- cell proliferation
- sentinel lymph node
- liquid chromatography
- neoadjuvant chemotherapy