Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders.
Rossana PassannanteVanessa Gómez-VallejoMaialen Sagartzazu-AizpuruaLaura Vignau ArsuagaPablo Marco-MorenoGarazi AldanondoAinara Vallejo-IllarramendiPablo AguiarUnai CossíoAbraham MartínJonas BergareLee KingstonCharles S ElmoreMiguel Ángel Morcillo AlonsoPablo FerrónJesus M AizpuruaJordi LlopPublished in: Biomedicines (2023)
-O-Ar and tertiary amine groups as the main pathways. PET studies suggest that knowledge about metabolic pathways is paramount to interpret images.