Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress.

Yuqing LiuYundan WangWei Ding Yingdeng Wang

Published in: Oxidative medicine and cellular longevity (2018)

Mito-TEMPO ameliorates renal fibrosis by alleviating mitochondrial dysfunction and endoplasmic reticulum stress possibly through the Sirt3-SOD2 pathway, which sheds new light on prevention of renal fibrosis in chronic kidney disease.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
oxidative stress
mouse model
ischemia reperfusion injury