Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury.

Zhiyuan YinLingling GeZhe ChaHui GaoLuodan AYuxiao ZengXiaona HuangXuan ChengKai YaoZui TaoHaiwei Xu

Published in: Stem cell research & therapy (2024)

Our results suggested the unique reprogramming properties of Hmga2 in regulating the fate transition of MG and neuroprotective effects on the retina with acute injury. This work uncovers the reprogramming ability of epigenetic factors in MG.

Keyphrases

liver failure
cell fate
respiratory failure
diabetic retinopathy
drug induced
aortic dissection
dna methylation
gene expression
optical coherence tomography
optic nerve
hepatitis b virus
type diabetes
intensive care unit
metabolic syndrome
extracorporeal membrane oxygenation
mechanical ventilation