Employing a chiroptical sensor for the absolute stereochemical determination of α-amino and α-hydroxyphosphonates.
Debarshi ChakrabortyLi ZhengYijing DaiJeff GwasdacusJames E McTigheWilliam D WulffBabak BorhanPublished in: Chemical communications (Cambridge, England) (2023)
The absolute stereochemistry of the α-amino and α-hydroxyphosphonates is determined using a chiroptical sensor. The induced helicity of the host-guest complex is correlated to the chirality of the guest molecule via a simple binding model. The relative size of the substituents dictates the predominant helical population, leading to an easy circular dichroic readout.