Effects of oral ısotretinoin on normal and wounded nasal mucosa: an experimental study.

Abdurrahman Bugra CengizCemal OzyilmazAlper TabaruSerkan KayabasiSertug Sinan EgeSedat RuzgarFunda EmreMehmet Faruk Oktay

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2018)

Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes.

Keyphrases

stem cells
oxidative stress
single cell
cell therapy
early onset
optical coherence tomography
peripheral blood
bone marrow
wound healing
mesenchymal stem cells