Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.
Thássio Ricardo R MesquitaYen-Nien LinShuang ChenYoungho LeeRodrigo Miguel-Dos-SantosAsli E AticiMichael C FishbeinMagali Noval RivasMoshe ArditiEugenio CingolaniPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.