High rates of indeterminate interferon-gamma release assays for the diagnosis of latent tuberculosis infection in liver transplantation candidates.
Alan J WiggSumudu K NarayanaShahzaib AnwarJeyamani RamachandranKate MullerJohn W ChenLibby JohnPravin HissariaBillingsley KaambwaRichard J WoodmanPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2019)
Our study suggests a high rate of INDT IGRA results during screening of liver transplant candidates for LTBI, associated with severity of liver disease and anergy. Because of the high rate of INDT QFT-G testing in this setting, individualized risk assessment is required including a thorough assessment of clinical risk factors and knowledge of local TB prevalence.