BOLD sensitivity and vessel size specificity along CPMG and GRASE echo trains.

CPMG or GRASE can be used with low refocusing flip angles without significant loss of sensitivity to BOLD. The evolution of BOLD signal changes along the echo train can be used to design optimal k-space reordering schemes. Signals acquired before or after the spin echo time point show contributions from larger vessels similar to gradient echo sequences. Short echo spacing (time between refocusing pulses) suppresses gradient echo-related contributions from larger vessels, whereas the spin echo-related contribution from small vessels remains constant and is independent of the echo spacing.