An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations.
Deepankar ChakrobortyVeera K OjalaAnna M KnittleJasmin DrexlerMahlet Z TamiratRegina RuzickaKarin BoschJohanna WoertlSusanne SchmittnerLaura L EloMark S JohnsonKari J KurppaFlavio SolcaKlaus EleniusPublished in: Cancer research communications (2022)
ERBB4 is a member of the ERBB family of oncogenes that is frequently mutated in different cancer types but the functional impact of its somatic mutations remains unknown. Here, we have analyzed the function of over 8,000 randomly mutated ERBB4 variants in an unbiased functional genetics screen. The data indicate the presence of rare activating ERBB4 mutations in cancer, with potential to be targeted with clinically approved pan-ERBB inhibitors.