Disruption of the GABAergic system contributes to the development of perioperative neurocognitive disorders after anesthesia and surgery in aged mice.
Wen ZhangBing-Rui XiongLong-Qing ZhangXian HuangWen-Chang ZhouQian ZouAnne ManyandeJie WangXue-Bi TianYu-Ke TianPublished in: CNS neuroscience & therapeutics (2020)
Anesthesia and surgery caused neuroinflammation in the hippocampus, which consequently disrupted the GABAergic system, increased the expressions of surface α5GABAA Rs especially through the P38 MAPK signaling pathway, and eventually led to hippocampus-dependent memory dysfunctions.
Keyphrases
- minimally invasive
- coronary artery bypass
- signaling pathway
- cerebral ischemia
- cognitive impairment
- surgical site infection
- traumatic brain injury
- cardiac surgery
- epithelial mesenchymal transition
- working memory
- type diabetes
- adipose tissue
- subarachnoid hemorrhage
- metabolic syndrome
- coronary artery disease
- inflammatory response
- functional connectivity