TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy.
Siri Amanda TvingsholmMarcus Svensson FrejVibeke Mindahl RafaUlla Kring HansenMaria OrmhøjAlexander TyronAgnete Witness Præst JensenMohammad KadivarAmalie Kai BentzenKamilla K MunkGitte N AasbjergJeppe S H TernanderChristina HeekeTripti TamhaneChristian SchmeesSamuel A FuntJulie Westerlin KjeldsenAnders Handrup KvernelandÖzcan MetArianna DraghiSøren Nyboe JakobsenMarco DoniaInge Marie SvaneSine Reker HadrupPublished in: Journal for immunotherapy of cancer (2023)
Taken together, the Ag-scaffold represents a promising new technology for selective expansion of antigen-specific CD8+ T cells directly from blood, yielding a highly specific and functionally enhanced T-cell product for ACT.