In the title compound, {[Zn 2 (C 12 H 12 O 4 ) 2 (C 11 H 10 N 4 O)(H 2 O)]·3H 2 O} n , monoperiodic coordination polymer double strands are held into the triperiodic crystal structure by means of N-H⋯O hydrogen-bonding patterns between the amide groups of the 1,3-di(pyridin-4-yl)urea ligands and unligated O atoms belonging to 5- tert -butyl-isophthalate ligands. One of the Zn atoms displays a tetra-hedral coordination environment, while the other Zn atom adopts a five-coordinate geometry inter-mediate between square pyramidal and trigonal bipyramidal. Additionally, O-H⋯O hydrogen-bonding patterns involving the water mol-ecules of crystallization serve as a structure-stabilizing element by aggregating the double-strand motifs.