Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.

Florent BarryFeng ChaiHenry Chijcheapaza-FloresMaria José Garcia-FernandezNicolas BlanchemainRomain Nicot

Published in: PloS one (2023)

MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.

Keyphrases

chronic pain
high glucose
diabetic rats
rheumatoid arthritis
high resolution
oxidative stress
drug induced
knee osteoarthritis
spinal cord