TGF-β1 peptide-based inhibitor P144 ameliorates renal fibrosis after ischemia-reperfusion injury by modulating alternatively activated macrophages.

Delun LiJian ZhangSiyu YuanChao WangJiakai ChangYan TongRan LiuTian SangLili LiJijun LiQing OuyangXiangmei Chen

Published in: Cell proliferation (2022)

Our study showed that the TGF-β1 peptide-based inhibitor P144 decreased renal fibrosis through the blockade of the TGF-β1-Smad3 signaling pathway and the modulation of macrophage polarization, suggesting its potential therapeutic use in IRI-induced renal fibrosis.

Keyphrases

transforming growth factor
signaling pathway
epithelial mesenchymal transition
ischemia reperfusion injury
oxidative stress
pi k akt
liver fibrosis
diabetic rats
mouse model
induced apoptosis
endoplasmic reticulum stress
stress induced