The Hyperintense study: Assessing the effects of induced blood pressure increase and decrease on MRI markers of cerebral small vessel disease: Study rationale and protocol.
Esther JanssenAnnemieke Ter TelgteEsmée VerburgtJoost Ja de JongJosé P MarquesRoy Pc KesselsWalter H BackesMarnix C MaasFrederick J A MeijerJaap DeinumNiels P RiksenAnil M TuladharFrank-Erik de LeeuwPublished in: European stroke journal (2022)
The Hyperintense study will improve the understanding of the pathophysiological mechanisms following hypertension that may cause SVD. This knowledge can ultimately help to identify new targets for treatment of SVD, aimed at prevention or limiting disease progression.