Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia.
Neveen L MikhaelMyriam Abo Seif H GendiHoda HassabElshaymaa A MegahedPublished in: International journal of hematologic oncology (2019)
Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.
Keyphrases
- acute lymphoblastic leukemia
- cerebrospinal fluid
- blood brain barrier
- single cell
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- bone marrow
- immune response
- dendritic cells
- protein protein
- liver injury
- amino acid
- risk assessment
- young adults
- binding protein
- early life
- childhood cancer
- free survival