Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination.
Laura ChoteauHélène VancraeynesteDidier Le RoyLaurent DubuquoyLuiginia RomaniThierry JouaultDaniel PoulainBoualem SendidThierry CalandraThierry RogerSamir JawharaPublished in: Gut pathogens (2017)
In contrast to TLR6, both TLR1 and TLR2 deficiencies increased intestinal inflammation, and the overgrowth of C. albicans and E. coli populations in the colitis model, suggesting the involvement of TLR1 and TLR2 in epithelial homeostasis, and a role of TLR6 in increasing intestinal inflammation in response to pathogen-sensing.