Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.
Charles E BreezeAnna BatorskyMi Kyeong LeeMindy D SzetoXiaoguang XuDaniel L McCartneyRong JiangAmit PatkiHolly J KramerJames M EalesLaura RaffieldLeslie LangeEthan LangePeter DurdaYongmei LiuRuss P TracyDavid Van Den Bergnull nullKathryn L EvansWilliam E KrausSvati ShahHermant K TiwariLifang HouEric A WhitselXiao JiangFadi J CharcharAndrea A BaccarelliStephen S RichAndrew P MorrisMarguerite R IrvinDonna K ArnettElizabeth R HauserJerome I RotterAdolfo CorreaCaroline HaywardSteve HorvathRiccardo E MarioniMaciej TomaszewskiStephan BeckSonja I BerndtStephanie J LondonJosyf C MychaleckyjNora FranceschiniPublished in: Genome medicine (2021)
We uncovered trans-ethnic and ethnic-specific DMPs associated with eGFR, including DMPs enriched in regulatory elements in kidney tissue and pathways related to kidney development. These findings shed light on epigenetic mechanisms associated with kidney function, bridging the gap between population-specific eGFR-associated DNAm and tissue-specific regulatory context.