Metabolic, Oxidative and Psychological Stress as Mediators of the Effect of COVID-19 on Male Infertility: A Literature Review.
Gesthimani MintzioriLeonidas H DuntasStavroula VenetiDimitrios G GoulisPublished in: International journal of environmental research and public health (2022)
Over 300 million patients with coronavirus disease 2019 (COVID-19) have been reported worldwide since the outbreak of the pandemic in Wuhan, Hubei Province, China. COVID-19 is induced by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effect of SARS-CoV-2 infection on the male reproductive system is unclear. The aim of this review is to assess the effect of SARS-CoV-2 infection on male fertility and the impact of possible mediators, such as metabolic, oxidative and psychological stress. SARS-CoV-2 infection aggravates metabolic stress and directly or indirectly affects male fertility by reducing seminal health. In addition, SARS-CoV-2 infection leads to excessive production of reactive oxygen species (ROS) and increased psychological distress. These data suggest that SARS-CoV-2 infection reduces male fertility, possibly by means of metabolic, oxidative and psychological stress. Therefore, among other consequences, the possibility of COVID-19-induced male infertility should not be neglected.
Keyphrases
- respiratory syndrome coronavirus
- coronavirus disease
- sars cov
- reactive oxygen species
- healthcare
- public health
- type diabetes
- dna damage
- sleep quality
- body mass index
- case report
- hepatitis b virus
- young adults
- south africa
- social media
- intensive care unit
- high glucose
- machine learning
- oxidative stress
- liver failure
- physical activity
- weight gain
- polycystic ovary syndrome
- climate change
- respiratory failure
- health information
- insulin resistance