Neurodegenerative diseases (NDs) refer to a group of diseases in which slow, continuous cell death is the main pathogenic event in the nervous system. Most NDs are characterized by cognitive dysfunction or progressive motor dysfunction. Treatments of NDs mainly target alleviating symptoms, and most NDs do not have disease-modifying drugs. The pathogenesis of NDs involves inflammation and apoptosis mediated by mitochondrial dysfunction. Dantrolene, approved by the US Food and Drug Administration, acts as a RyRs antagonist for the treatment of malignant hyperthermia, spasticity, neuroleptic syndrome, ecstasy intoxication and exertional heat stroke with tolerable side effects. Recently, dantrolene has also shown therapeutic effects in some NDs. Its neuroprotective mechanisms include the reduction of excitotoxicity, apoptosis and neuroinflammation. In summary, dantrolene can be considered as a potential therapeutic candidate for NDs.
Keyphrases
- oxidative stress
- cell death
- drug administration
- cell cycle arrest
- endoplasmic reticulum stress
- multiple sclerosis
- spinal cord injury
- cerebral ischemia
- atrial fibrillation
- heat stress
- risk assessment
- case report
- climate change
- botulinum toxin
- inflammatory response
- combination therapy
- upper limb
- drug induced
- replacement therapy