Flow inefficiencies in non-obstructive HCM revealed by kinetic energy and hemodynamic forces on 4D-flow CMR.

K Pola Zakariye AshkirS MyersonHåkan Arheden Hugh C Watkins Stefan NeubauerP M ArvidssonBetty Raman

Published in: European heart journal. Imaging methods and practice (2024)

Despite normal flow velocities on echocardiography, patients with non-obstructive HCM exhibited greater stroke work, systolic KE and HDF ratio, and late diastolic KE relative to controls. 4D-flow CMR provides more sensitive measures of haemodynamic inefficiencies in HCM, holding promise for clinical trials of novel therapies and clinical surveillance of non-obstructive HCM.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
clinical trial
blood pressure
heart failure
public health
atrial fibrillation
pulmonary hypertension
machine learning
big data
brain injury
open label
blood brain barrier
phase ii