Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy.

Chi ZhangWei ZhangDashuai ZhuZhenhua LiZhenzhen WangJunlang LiXuan MeiWei XuKe ChengBiao Zhong

Published in: Journal of nanobiotechnology (2022)

In a rat model of osteoporosis, MSC-Sec/CXCR4 NP were found to accumulate in bone, and such treatment inhibited osteoclast differentiation while promoting osteogenic proliferation. In addition, our results showed that MSC-Sec/CXCR4 NPs reduce OVX-induced bone mass attenuation in OVX rats.

Keyphrases

bone mineral density
postmenopausal women
stem cells
bone loss
cell migration
body composition
mesenchymal stem cells
high glucose
endothelial cells
soft tissue
bone marrow
signaling pathway
diabetic rats
bone regeneration
cancer therapy
drug delivery
mass spectrometry