Novel acridine-based thiosemicarbazones as 'turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study.
Ibanga Okon IsaacIqra MunirMariya Al-RashidaSyed Abid AliZahid ShafiqMuhammad IslamRalf LudwigKhurshid AyubKhalid Mohammed KhandAbdul HameedPublished in: Royal Society open science (2018)
New thiosemicarbazide-linked acridines 3a-c were prepared and investigated as chemosensors for the detection of biologically and environmentally important anions. The compounds 3a-c were found selective for fluoride (F-) with no affinity for other anions, i.e. -OAc, Br-, I-, HSO4-, SO42-, PO43-, ClO3-, ClO4-, CN- and SCN-. Further, upon the gradual addition of a fluoride anion (F-) source (tetrabutylammonium fluoride), a well-defined change in colour of the solution of probes 3a-c was observed. The anion-sensing process was studied in detail via UV-visible absorption, fluorescence and 1H-NMR experiments. Moreover, during the synthesis of acridine probes 3a-c nickel fluoride (NiF2), a rarely explored transition metal fluoride salt, was used as the catalyst. Theoretical studies via density functional theory were also carried out to further investigate the sensing and anion (F-) selectivity pattern of these probes.
Keyphrases
- ionic liquid
- drinking water
- density functional theory
- single molecule
- living cells
- small molecule
- transition metal
- fluorescence imaging
- molecular dynamics
- fluorescent probe
- gold nanoparticles
- squamous cell carcinoma
- solid state
- photodynamic therapy
- lymph node metastasis
- quantum dots
- atomic force microscopy
- loop mediated isothermal amplification