Assessing the potential for precision medicine in body weight reduction with regard to type 2 diabetes mellitus therapies: A meta-regression analysis of 120 randomized controlled trials.
Kris G VargasTobias RüttenBenedikt SiemesMaximilian BrockmeyerClaudio ParcoAlexander HossSabrina SchlesingerChristian JungMichael RodenMalte KelmGeorg WolffOliver KußPublished in: Diabetes, obesity & metabolism (2024)
We found no major treatment response heterogeneity in RCTs of glucose-lowering drugs for body weight reduction in type 2 diabetes. The precision medicine approach may thus be of limited value in this setting.