Bioactive 5/5/5/6 Four-Ring System Iridoids from Plumeria alba L.
Xin ZhouXin-Bin MengXue-Ming ZhouZheng-Tian ZhuJing YangHong-Jie ChenXin-Ming SongPublished in: Chemistry & biodiversity (2024)
Two rare 5/5/5/6 four-ring system iridoids, allamancins A and B (1 and 2) together with one known biogenetically related iridoid derivative, 3-O-methyallamancin (3) were isolated from the flowers of Plumeria alba L. The structures of these iridoid derivatives were determined by comprehensive spectroscopic analyses. The absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of compounds 1-3 against nitric oxide (NO) production induced and three cancer cell lines were evaluated in vitro. Compounds 1 and 3 showed inhibitory activities on NO production with IC 50 values of 18.3±0.12 and 22.1±0.14 μM, respectively. Compounds 1-3 showed moderate inhibitory activities against cancer cell lines of A549, Hela and MCF-7.
Keyphrases
- papillary thyroid
- nitric oxide
- squamous cell
- high resolution
- molecular docking
- high glucose
- squamous cell carcinoma
- high intensity
- breast cancer cells
- diabetic rats
- drug induced
- hydrogen peroxide
- magnetic resonance
- mass spectrometry
- computed tomography
- signaling pathway
- molecular dynamics simulations
- pi k akt
- dual energy