Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.

Hila IsraelovOrly RavidDana AtrakchiDaniel RandShirin ElhaikYael BreslerRachel Twitto-GreenbergLiora OmesiSigal Liraz-ZaltsmanFabien GosseletMichal Schnaider BeeriItzik Cooper

Published in: Journal of neuroinflammation (2020)

These results shed light on the important role of caspase-1 in BBB insult in general and specifically in the inflamed endothelium, and suggest therapeutic potential for various CNS disorders, by targeting caspase-1 in the injured BBB.

Keyphrases

blood brain barrier
cell death
induced apoptosis
cerebral ischemia
endoplasmic reticulum stress
oxidative stress
signaling pathway