An Experimental Study on The Oxidative Status and Inflammatory Levels of A Rat Model of Polycystic Ovary Syndrome Induced by Letrozole and A New High-Fat Diet.

Seyyede Fahimeh Mirseyyed Saeed Zavareh Meysam Nasiri Hamid Hashemi-Moghaddam

Published in: International journal of fertility & sterility (2023)

The combination of a new HFD and letrozole treatment induces inflammation and oxidative stress (OS) in a rat model of PCOS. This model accurately exhibits abnormal metabolic phenotypes and disruptions in hormonal profiles associated with PCOS.

Keyphrases

polycystic ovary syndrome
high fat diet
insulin resistance
oxidative stress
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
dna damage
diabetic rats
ischemia reperfusion injury
induced apoptosis
replacement therapy
endoplasmic reticulum stress
heat stress
heat shock protein