The role of allogeneic stem-cell transplant in myelofibrosis in the era of JAK inhibitors: a case-based review.
Mario TiribelliFrancesca PalandriEmanuela Sant'AntonioMassimo BrecciaMassimiliano BonifacioPublished in: Bone marrow transplantation (2019)
Allogeneic hematopoietic stem-cell transplantation (HSCT) is, at present, the only potentially curative therapy for myelofibrosis (MF). Despite many improvements, outcomes of HSCT are still burdened by substantial morbidity and high transplant-related mortality. Allogeneic transplant is generally considered in intermediate-2 and high-risk patients aged <70 years, but the optimal selection of patients and timing of the procedure remains under debate, as does as the role of JAK inhibitors in candidates for HSCT. Starting from a real-life clinical case scenario, herein we examine some of the crucial issues of HSCT for MF in light of recent refinements on MF risk stratification, data on the use of ruxolitinib before and after transplant and findings on the impact of different conditioning regimens and donor selection.
Keyphrases
- end stage renal disease
- hematopoietic stem cell
- stem cells
- allogeneic hematopoietic stem cell transplantation
- ejection fraction
- chronic kidney disease
- stem cell transplantation
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- bone marrow
- acute lymphoblastic leukemia
- type diabetes
- machine learning
- cardiovascular disease
- metabolic syndrome
- mesenchymal stem cells
- risk factors
- deep learning
- skeletal muscle
- weight loss
- low dose
- adipose tissue
- minimally invasive
- artificial intelligence
- rectal cancer