Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
Sarvenaz MetghalchiMarie VandestienneYacine HaddadBruno EspositoJulien DairouAlain TedguiZiad MallatStephane PotteauxSoraya TalebPublished in: PloS one (2018)
Our study showed that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
Keyphrases
- high fat diet
- angiotensin ii
- low density lipoprotein
- insulin resistance
- adipose tissue
- coronary artery
- angiotensin converting enzyme
- vascular smooth muscle cells
- oxidative stress
- wild type
- endoplasmic reticulum stress
- diabetic rats
- cell death
- abdominal aortic aneurysm
- drug induced
- cell cycle arrest
- type diabetes
- skeletal muscle
- cell proliferation
- binding protein