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Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.

Sarvenaz MetghalchiMarie VandestienneYacine HaddadBruno EspositoJulien DairouAlain TedguiZiad MallatStephane PotteauxSoraya Taleb
Published in: PloS one (2018)
Our study showed that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
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