The Association of Mitochondrial Copy Number With Sarcopenia in Adult Survivors of Childhood Cancer.

Kelly McCastlain Carrie R HowellCatherine E WelshZhaoming WangCarmen L WilsonHeather L Mulder John Easton Ann C Mertens Jinghui Zhang Yutaka Yasui Melissa M Hudson Leslie L Robison Mondira Kundu Kristen K Ness

Published in: Journal of the National Cancer Institute (2022)

A growing body of evidence supports peripheral blood mtDNAcn as a biomarker for adverse health outcomes; however, this study is the first to report an association between mtDNAcn and sarcopenia among childhood cancer survivors.

Keyphrases

childhood cancer
young adults
copy number
peripheral blood
mitochondrial dna
skeletal muscle
genome wide
oxidative stress
dna methylation
community dwelling
gene expression
emergency department
adverse drug
electronic health record