Fe-Doped MoS 2 Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant.

The peroxidase-like catalytic activity of various nanozymes was extensively applied in various fields. In this study, we have demonstrated the preparation of Fe-doped MoS 2 (Fe@MoS 2 ) nanomaterials with enhanced peroxidase-like activity of MoS 2 in a co-catalytic pathway. In view of Fenton reaction, the peroxidase-like Fe@MoS 2 nanozyme prompted the decomposition of hydrogen peroxide (H 2 O 2 ) to a reactive hydroxyl radical (·OH). The efficient decomposition of H 2 O 2 in the presence of Fe@MoS 2 has been employed toward the antibacterial activity and detoxification of mustard gas simulant. The combined effect of Fe@MoS 2 and H 2 O 2 showed remarkable antibacterial activity against the drug-resistant bacterial strain methicillin-resistant Staphylococcus aureus and Escherichia coli with the use of minimal concentration of H 2 O 2 . Fe@MoS 2 was further applied for the detoxification of the chemical warfare agent sulfur mustard simulant, 2-chloroethyl ethyl sulfide, by selective conversion to the nontoxic sulfoxide. This work demonstrates the development of a hybrid nanozyme and its environmental remediation from harmful chemicals to microbes.