In this study, we focus on the following question: do genomic regions enriched in cancer variant mutations have significantly different chromatin folding patterns? We utilize publicly available Hi-C data to characterize chromatin folding patterns in healthy (GM12878) and cancer (K562) cells based on status of A/B compartmentalization and random vs non-random chromatin physical interactions. We then perform statistical testing to assess if chromatin folding patterns in cancer variant-enriched loci are significantly different from non-enriched loci. Our results indicate that loci with cancer variant status have significantly altered (FDR < 0.05) chromatin folding patterns.
Keyphrases
- genome wide
- papillary thyroid
- gene expression
- dna damage
- transcription factor
- squamous cell
- single molecule
- molecular dynamics simulations
- dna methylation
- squamous cell carcinoma
- induced apoptosis
- physical activity
- genome wide association study
- machine learning
- deep learning
- endoplasmic reticulum stress
- young adults
- cell death
- cell cycle arrest