Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1.
Caleb A PadgettRóbert K BátoriAndrew C SpeeseCody L RosewaterWeston B BushCassandra C DerellaStephen B HaighHunter G SellersZachary L CorleyMadison A WestJames D MintzBrittany B AngeRyan A HarrisMichael W BrandsDavid J R FultonDavid W SteppPublished in: bioRxiv : the preprint server for biology (2023)
mice, likely through a NOX1-mediated mechanism. Pathological levels of GAL3 and in turn, NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.