A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A1c With Implications for Glycemic Status in U.S. Hispanics/Latinos.

Jee-Young MoonTin L LouieDeepti JainTamar SoferClaudia SchurmannJennifer E BelowChao-Qiang LaiM Larissa Aviles-SantaGregory A TalaveraCaren E SmithLauren E PettyErwin P BottingerYii-Der Ida ChenKent D TaylorMartha L DaviglusJianwen CaiTao WangKatherine L TuckerJosé M OrdovásCraig L HanisRuth J F LoosNeil SchneidermanJerome I RotterRobert C KaplanQibin Qi

Published in: Diabetes care (2019)

This study in U.S. Hispanics/Latinos found several ancestry-specific alleles associated with HbA1c through erythrocyte-related rather than glycemic-related pathways. The potential influences of these nonglycemic-related variants need to be considered when the HbA1c test is performed.

Keyphrases

type diabetes
genome wide association study
risk assessment
gene expression
adipose tissue
genome wide
weight loss
human health