Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome.

Livia Cosentino Chiara Urbinati Chiara Lanzillotta Domenico De Rasmo Daniela ValentiMattia PellasMaria Cristina Quattrini Fabiana Piscitelli Magdalena Kostrzewa Fabio Di Domenico Donatella Pietraforte Tiziana Bisogno Anna Signorile Rosa Anna Vacca Bianca De Filippis

Published in: Molecular autism (2024)

The present data identify mtCB1R overexpression as a novel molecular alteration in the RTT mouse brain that may underlie defective brain mitochondrial bioenergetics and cognitive dysfunction.

Keyphrases

mouse model
resting state
oxidative stress
white matter
functional connectivity
cerebral ischemia
cell proliferation
electronic health record
transcription factor
case report
big data
multiple sclerosis