PHLPP1 deficiency protects against age-related intervertebral disc degeneration.
Changli ZhangKatherine M JosephNazir M KhanMartha Elena Diaz-HernandezHicham DrissiSvenja Illien-JüngerPublished in: JOR spine (2022)
deficiency protected against NP phenotypic changes, extracellular matrix degradation, and cell apoptosis in the process of IVD degeneration, probably through FOXO1 activation, making PHLPP1 a promising therapeutic target for treating IVD degeneration.