The Variants in the 3' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma.

Sandra DragicevicMitja KosnikAleksandra Divac RankovMatija RijavecKatarina MilosevicPeter KorosecMaja Skerbinjek KavalarAleksandra Nikolic

Published in: Lung (2018)

The main finding of our study is the association of MMP9 genotypes rs20544 TT and rs13925 AA and AG with better asthma control, and indirectly better response to treatment. Based on these results, MMP9 deserves further research as a potential predictive biomarker for asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
copy number
young adults
small molecule
cell migration
genome wide
air pollution
cystic fibrosis
gene expression
transcription factor
genome wide identification