High prevalence of maternal mosaic monosomy X in pregnant women in Vietnam.
Danh Cuong TranThanh-Thanh Thi NguyenNgoc-Lan Thi HoangLan-Anh Thi LuongKim-Phuong Thi DoanMinh Thi Thi HaNhat-Thang TranVan-Thong NguyenThu-Huong Nhat TrinhNgoc-Trinh Kieu NguyenCong-Trai NguyenThanh-Dat NguyenxQuynh-Tho Thi NguyenThanh-Thuy Thi DoDinh-Kiet TruongHoa GiangHoai-Nghia NguyenHung-Sang TangMinh Duy PhanPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2022)
We found a relatively high prevalence of MMXO in Vietnamese pregnant women and demonstrated a strong influence of MMXO on the ChrX z-score using a count-based method, resulting in false positives. The size-based method is not sensitive to MMXO and therefore achieves higher PPV.