Perivascular and endomysial macrophages expressing VEGF and CXCL12 promote angiogenesis in anti-HMGCR immune-mediated necrotizing myopathy.

Anna LiaTiziana AnneseMarco FornaroMargherita GianniniDario D'AbbiccoMariella ErredeLoredana LorussoAngela AmatiMarilina TampoiaMaria TrojanoDaniela VirgintinoDomenico RibattiLuigi SerlengaFlorenzo Iannone Francesco Girolamo

Published in: Rheumatology (Oxford, England) (2021)

Our findings suggest that in IIMs, infiltrating macrophages and microvascular cells interactions play a pivotal role in coordinating myogenesis and angiogenesis. This reciprocal crosstalk seems to distinguish anti-HMGCR associated IMNM.

Keyphrases

vascular endothelial growth factor
endothelial cells
induced apoptosis
cell cycle arrest
late onset
wound healing
cell death
endoplasmic reticulum stress
pi k akt