NTRK-rearranged spindle cell neoplasms are ubiquitous tumors of myofibroblastic lineage with a distinct methylation class.

Arnault Tauziède-EspariatMathilde DuchesneJessica BaudMégane Le QuangDorian BochatonRihab AzmaniSabrina CroceIsabelle HosteinCarole KesrouaniDelphine GuillemotGaëlle PierronFranck BourdeautLiesbeth CardoenLauren HastyEmmanuèle LechaptAlice MétaisFabrice ChrétienStéphanie PugetPascale VarletFrançois Le Loarer

Published in: Histopathology (2022)

Our findings confirm that SCN-NTRK share similar features in adults and children and in all locations combine an infiltrative pattern, distinct epigenetic and transcriptomic profiles, and ultrastructural evidence of a myofibroblastic lineage. Further studies may support the use of new terminology to better describe their myofibroblastic nature.

Keyphrases

single cell
rna seq
dna methylation
gene expression
young adults
genome wide
stem cells
cell fate
bone marrow